Fatores psicossociais e biológicos nos portadores de sofrimento psíquico atendidos no CAPS II - Bagé

Abstract

This study investigated psychopathological, psychosocial and biological indicators on the population that seeks attention in the Centro de Atenção Psicossocial (CAPS II) Bagé, from July 2013 to October 2014. This thesis proposes two objectives: 1) to evaluate the serum NGF levels in psychiatric patients and to verify a possible association between serum NGF levels and functionality; and 2) to evaluate the association between risk of suicide, mental disorders and trauma in childhood. This was a cross-sectional study with a sample made for convenience. In total, 376 individuals were evaluated, of both sexes, aged from 19 y-old, who held the first service in this specialized health unit. The diagnostic evaluation, as well as the presence of suicide risk was performed using structured clinical interview Mini Plus (DSM-IV TR). The presence of traumatic events was assessed by the Questionnaire on trauma in childhood and / or adolescence (CTQ). Functionality was assessed through the Functioning Assessment Short Test (FAST) scale. Finally, the collection of biological material was performed to measure the serum levels of NGF, using ELISA method. Statistical analyzes were performed using SPSS 22.0. NGF levels were significantly increased in patients with obsessive-compulsive disorder and generalized anxiety disorder as compared to patients without these disorders. NGF was negatively associated with the domains of autonomy and cognition. Suicide risk was associated with greater trauma scores in childhood. In the adjusted analysis after control for age and socioeconomic status, suicide risk remained associated with childhood trauma (p = 0.039) and the domains of emotional abuse (p = 0.027) and emotional neglect (p = 0.044). Such evidence increases the need for a better understanding of interaction between psychosocial factors and mental disorders to develop forms of protective attention to psychological distress and risk of suicide, making prevention a priority in the CAPS and the entire network of care in public policies.