Alterações no receptor CRHR1 e níveis de Il-1B no comportamento suicida

Abstract

Introduction: Suicide is one of the ten leading causes of death worldwide, emerging from a complex interaction between genetic, environmental and psychosocial factors. In this aspect studies found that individuals with suicidal tendencies have elevations in the levels of pro-inflammatory cytokines and alterations in the functioning of the HPA axis. Objective: Investigate the association of the polymorphism in the CRHR1 gene (rs110402) with the suicidal behavior, as well as the genotype effects on IL-1β levels. Methods: Sample consisted in 171 individuals that participated in the study, from which 15 were at risk of suicide, 20 had attempted suicide and 136 were controls. We perform genotyping of individuals by real-time PCR and IL-1β levels measured by ELISA technique. Results: Individuals with a clinical diagnosis of attempted suicide carrying the A allele of SNP rs110402 showed increased IL-1β levels (19.3 IQR: 6.84 to 36.47) compared to the control group (4.91 IQR: 3.22 to 6.39; p = 0.027). Ratings isolated from the levels of this interleukin and genotypes of the rs10402 SNP showed no relationship with suicidal behavior. Conclusion: Our results suggest that alterations in CRHR1 gene can affect the levels of pro-inflammatory molecules, showing the complex interactions of biological markers in suicidal behavior.