Índice inflamatório nutricional : associação com estado nutricional e avaliação da capacidade prognóstica de sobrevida de pacientes com câncer de trato gastrointestinal e de pulmão pré-quimoterapia

Abstract

Objective: To evaluate prognostic capacity of the Inflammatory-Nutritional Index (INI) in gastrointestinal and lung cancer patients. Methods: Longitudinal study, including patients of chemotherapy service in Brazil, between July-2008 and May-2010. INI (Albumin/CRP) and nutritional status (by Subjective Global Assessment - SGA) were evaluated. Risk INI was defined as lower than 0.35. The mean follow-up of survival was 1.6 year. Statistical analyses were performed using Kaplan-Meier survival estimates curves. Results: Seventy-four patients were enrolled, mean aged 63.4 years old, most of them male (58%) and presenting gastrointestinal cancer (71%). Malnutrition was identified in 87% of the patients (22% severely malnourished). The mean INI was 2.67 and 54% of the patients had INI levels considered as risk. During the follow-up there were 49 deaths (66%). The median time of survival for INI risk patients was significantly shorter than for normal INI ones (p=0.002). Fifty percent of INI risk subsample was dead after 0.78 year, while in the normal INI group death occurred after 2.78 years (p=0.001). INI risk and severe malnutrition were independent predictors for poor survival. Conclusion: The INI showed prognostic capacity in this sample and may be a useful tool, based on routinely available blood tests, to assess prognostic in cancer patients.