Avaliação dos níveis séricos de IL-1b em pacientes com episódio atual de depressão, mania ou episódio mistos

Abstract

Objective: The purpose of this study was to clarify the effect of imune response in diferente mood episodes. Methods: This report is part of a cross-sectional population-based study including 1560 individuals 18 to 35 year-old living in the urban area of Pelotas, RS (Brazil). We randomly selected 241 subjects from the population-based study. The diagnostic of current depression, mania or mixed episode was made using the Mini International Neuropsychiatric Interview 5.0 (MINI). Serum levels of IL-1b were measured using a commercial available immunoassay kit. Results: In the present work we found 110 (45.6%) patients with no current mood episode, 15 (6.2%) patients in maniac episodes, 91 (37.8%) patients with current depression and 25 (10.4%) patients in a mixed states. Socio-demographic variables like ethnicity and years in school were not significantly different between the groups. Regarding the cytokine measurements, patients in maniac and depressive episodes had similar levels of IL-1b (8.85 and 8.90 pg/mL, respectively) when compared to the group with no mood episodes (10.24 pg/mL). However, patients in mixed states had an increase (13.19 pg/mL) in IL-1b levels (P=0.09) when compared to the other groups. Discussion: These results suggest that mixed mood episodes are associated with higher levels of IL-1b. This pro-inflammatory state might underlie the symptom severity and the poor outcome observed in these patients